Protein Details: Aquaporin-9

Protein ID

ICDB_Pro_1533

Protein Name

Aquaporin-9

Gene Name

Aqp9

Organism

Mus musculus (Mouse)

Length

295 amino acids

AlphaFoldDB

AF-Q9JJJ3-F1-model_v4.pdb

Function

Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small; non-charged solutes including carbamides; polyols; purines; and pyrimidines.

Sequence

MPSEKDRAKKNLVQRLALKSCLAKETLSEFLGTFIMIVLGCGSIAQAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFPFYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLLITGENGTAFIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFDSRNLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFTFGNNFWWIPVVGPMIGAVLGGLIYVLFIQMHHSNPDPEVKAEPAENNLEKHELSVIM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1074/jbc.m001119200; 10.1126/science.1112014

RefSeq

NP_071309.1; XP_006511394.1; XP_006511395.1; XP_011241084.1; XP_011241085.1